The Buffalo Bills (8-6) will face off against the Los Angeles Chargers (5-9) on Saturday Night in Week 16 at SoFi Stadium. The Chargers have recently undergone a significant change in their leadership as their former head coach, Brandon Staley, and general manager, Tom Telesco, were fired due to their team’s ongoing struggles this season.
The Los Angeles Chargers suffered a 63-21 loss to the Las Vegas Raiders during Week 15 Thursday Night Football. Easton Stick completed 23 out of 32 passes for 257 yards, with three touchdowns and one interception against the Raiders. The Chargers will be without their starting quarterback, Justin Herbert, who broke his right index finger during the Broncos game in Week 14, ending his season early.
The Buffalo Bills had a remarkable 31-10 victory over the Dallas Cowboys during Week 15. The star performer of the game was running back James Cook, who achieved his career-best performance by recording 179 rushing yards on 25 carries and scoring one touchdown. However, the Bills may face a challenge in their upcoming game against the Chargers, as two key players, defensive end AJ Epenesa and safety Micah Hyde, may not be available due to injury. Epenesa is currently recovering from a rib injury while Hyde is dealing with a neck injury are will be considered a game-time decision.
How to watch Bills vs. Chargers: Odds and schedule for Week 16 Saturday Night Football
Buffalo Bills at Los Angeles Chargers Predictions:
BetMGM: Bills will win
Staff writes: “The winning team model predicts the Bills will win this Week 16 game with 79.1% confidence, based on game simulations, player injuries, offensive & defensive matchups and recent game results.”
ESPN: Bills have a 81% chance to win
According to the ESPN Matchup Predictor, the Buffalo Bills have a 81.7% chance of beating the Los Angeles Chargers in Week 16.
Dimers: Bills winning 25-16
Staff writes: “Our famous predictive analytics model currently gives the Bills an 82% chance of beating the Chargers in Week 16 of the NFL season, and our predicted final score has the Bills winning 25-16.”
Buffalo Bills at Los Angeles Chargers odds, betting lines
The Buffalo Bills are favorites to defeat the Los Angeles Chargers, according to the BetMGM NFL odds.
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- Spread: Bills (-12.5)
- Moneyline: Bills (-800); Chargers (+550)
- Over/under: 44
Buffalo Bills at Los Angeles Chargers injury news
Buffalo Bills:
| Player | Position | Injury | Status |
| Jordan Phillips | DT | Wrist | Injured Reserve |
| Justin Shorter | WR | Wrist | Injured Reserve |
| Micah Hyde | SS | Neck | Out for Week 16 |
| A.J. Epenesa | DE | Ribs | Questionable for Week 16 |
| Ty Johnson | RB | Shoulder | Questionable for Week 16 |
| Damien Harris | RB | Concussion | Injured Reserve |
| Kaiir Elam | CB | Ankle | Injured Reserve |
| Tommy Doyle | OT | Knee | Injured Reserve |
| Nyheim Hines | RB | Knee | Injured Reserve |
| Zach Davidson | TE | Undisclosed | Injured Reserve |
Los Angeles Chargers:
| Player | Position | Injury | Status |
| Justin Herbert | QB | Finger | Injured Reserve |
| Keenan Allen | WR | Heel | Out for Week 16 |
| Nick Williams | DT | Shoulder | Questionable for Week 16 |
| Nick Vannett | TE | Back | Questionable for Week 16 |
| Joey Bosa | LB | Foot | Injured Reserve |
| Will Clapp | C | Knee | Injured Reserve |
| Deane Leonard | CB | Ankle | Doubtful for Week 16 |
| Essang Bassey | DB | Concussion | Questionable for Week 16 |
| Tanner Muse | LB | Knee | Injured Reserve |
| Corey Linsley | C | Illness | Injured Reserve for Week 16 |
| Zack Bailey | OT | Back | Injured Reserve |
| Chris Rumph II | LB | Foot | Injured Reserve |
| Raheem Layne | SAF | Knee-ACL | Injured Reserve |
| Mike Williams | WR | Knee-ACL | Injured Reserve |
NFL: Chargers QB Justin Herbert out for remainder of season with fractured index finger
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